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KMID : 1002120080050020082
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Journal of Korean Sleep Research Society
2008 Volume.5 No. 2 p.82 ~ p.88
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The Effect of Sleep on Quality of Life in Cognitively Impaired Elder
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Kim Chun-Hwa
Jung Ju-Eun
Jang Mun-Seon
Kwak Ho-Wan
Park Sung-Pa
Lee Ho-Won
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Abstract
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Background: The prevalence of sleep disturbance in patients with Alzheimer’s disease (AD) is common. The purpose of this study is whether quality of sleep (QoS) has effect on quality of life (QoL) in Alzheimer’s disease (AD) patients and amnestic mild cognitive impairment (aMCI) patients or not.
Method: The participants were included 44 AD patients and 54 aMCI patients in this study. AD patients met NINCDS-ADRDA criteria for “probable” or “possible” AD and K-MMSE score was more than 16, single or multi domain aMCI patients met Peterson’s Criteria. The QoS was assessed by Pittsburgh Sleep Quality Index (PSQI) and the QoL by Medical Outcome Study Short From-36 (SF-36).
Result: Poor sleep was defined by PSQI score more than 6. Therefore, in AD group 23 patients were good sleepers and 21 patients were poor sleepers and in aMCI group 28 patents were good sleepers and 26 patents were poor sleepers. There was no significant difference in the demographic variables demographic factor and global cognitive function which was assessed by K-MMSE and CDR between good sleeper group and poorer sleep group. The poor sleeper group in AD and aMCI had significantly higher depression score and poorer QoL than good sleeper group. The depression played a role as a mediator between QoS and QoL.
Conclusion: QoS was also associated QoL in AD and aMCI and depression seemed to play a role as a mediating variable between QoS and QoL. Therefore, QoS had an effect on QoL indirectly rather than directly. In conclusion, sleep has a great effect on cognitively impaired elder, even in very early stage.
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KEYWORD
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Quality of life, Quality of sleep, Alzheimer’s disease, Mild cognitive impairment
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